Chemistry Heterocyclic Building Blocks Pyrimidines 5H-Pyrrolo[3,2-D]Pyrimidine

5H-Pyrrolo[3,2-D]Pyrimidine

Substitution Reactions: If there are electrophilic or nucleophilic functional groups on the molecule, it can undergo substitution reactions. For example, it can undergo nucleophilic aromatic substitution (SNAr) or electrophilic aromatic substitution (SEAr) reactions. Addition Reactions: Depending on the conditions, it can undergo addition reactions with electrophiles or nucleophiles. For instance, if it has a double bond, it might undergo addition reactions with electrophiles like halogens or nucleophiles. Oxidation and Reduction Reactions: 5H-pyrrolo[3,2-d]pyrimidine can undergo oxidation or reduction reactions depending on the conditions and reagents used. Ring-Opening Reactions: Under certain conditions, the pyrrolo[3,2-d]pyrimidine ring system can open, leading to the formation of open-chain compounds. Cyclization Reactions: It can undergo intramolecular cyclization reactions if there are suitable functional groups that can form new rings within the molecule. Halogenation: Depending on the presence of C-H bonds and the specific conditions, it can undergo halogenation reactions, where hydrogen atoms can be replaced by halogen atoms. Amination: It can be aminated to introduce amino groups under appropriate reaction conditions.

Further Reading:

Framework+−

(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine 1,4,5,6-Tetrahydropyrimidine 1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,4,5-Trichloropyrimidine 2,4,6-Trichloropyrimidine 2,4,6-Triphenylpyrimidine 2,4-Dichloro-6-Methylpyrimidine 2,4-Dichloropyrimidin-5-Amine 2,4-Dimethoxypyrimidine 2,4-Dimethylpyrimidine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(Chloromethyl)Pyrimidine 2-(Methylsulfonyl)Pyrimidine 2-(Methylthio)Pyrimidin-4-Amine 2-(Methylthio)Pyrimidine 2-(Piperazin-1-Yl)Pyrimidine 2-(Piperidin-1-Yl)Pyrimidine 2-(Propylthio)Pyrimidine 2-(Pyridin-2-Yl)Pyrimidine 2-(Pyrrolidin-1-Yl)Pyrimidine 2-(Trifluoromethyl)Pyrimidine 2-Aminopyrimidin-4(3H)-One 2-Bromopyrimidine 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-4-Methoxypyrimidine 2-Chloro-4-Methylpyrimidine 2-Chloro-4-Phenylpyrimidine 2-Chloro-5-Fluoropyrimidine 2-Chloro-5-Methylpyrimidine 2-Chloro-5-Nitropyrimidine 2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine 2-Chloropyrimidin-4-Amine 2-Cyclopropylpyrimidine 2-Ethoxypyrimidine 2-Ethylpyrimidine 2-Fluoropyrimidine 2-Hydrazineylpyrimidine 2-Iodopyrimidine 2-Methoxypyrimidin-4-Amine 2-Methoxypyrimidine 2-Methylpyrimidin-4-Amine 2-Methylpyrimidin-4-Ol 2-Phenoxypyrimidine 2-Phenylpyrimidin-5-Amine 3-Methylpyrimidin-4(3H)-One 4,5-Dichloropyrimidine 4,6-Dichloro-2-(Methylthio)Pyrimidine 4,6-Dichloro-2-Methylpyrimidine 4,6-Dichloropyrimidin-2-Amine 4,6-Dichloropyrimidine 4,6-Diphenylpyrimidine 4-(Dimethoxymethyl)Pyrimidine 4-(Piperazin-1-Yl)Pyrimidine 4-(Piperidin-1-Yl)Pyrimidine 4-(Pyridin-3-Yl)Pyrimidine 4-(Pyrimidin-2-Yl)Morpholine 4-(Pyrimidin-4-Yl)Morpholine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 4-Bromopyrimidine 4-Chloro-2-(Methylthio)Pyrimidine 4-Chloro-2-Methoxypyrimidine 4-Chloro-2-Phenylpyrimidine 4-Chloro-5-Fluoro-2-Methylpyrimidine 4-Chloro-5-Iodopyrimidine 4-Chloro-5-Methoxypyrimidine 4-Chloro-5-Methylpyrimidine 4-Chloro-6-Methoxypyrimidine 4-Chloropyrimidin-2-Amine 4-Chloropyrimidin-5-Amine 4-Chloropyrimidine-5-Carbonitrile 4-Ethoxypyrimidine 4-Fluoropyrimidine 4-Iodopyrimidine 4-Methoxy-2-Methylpyrimidine 4-Methoxypyrimidin-2-Amine 4-Methoxypyrimidine 4-Methyl-2-(Methylthio)Pyrimidine 4-Methylpyrimidin-2-Amine 4-Methylpyrimidine 4-Phenoxypyrimidine 4-Phenylpyrimidin-2-Amine 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine 5-(Benzyloxy)Pyrimidine 5-Benzylpyrimidine 5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Bromo-2-(Methylthio)Pyrimidine 5-Bromo-2-Chloropyrimidine 5-Bromo-2-Methylpyrimidine 5-Bromo-4-Chloropyrimidine 5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Bromopyrimidin-4(3H)-One 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Ethylpyrimidine 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Iodopyrimidine 5-Methylpyrimidine 5-Phenylpyrimidine 5H-Pyrrolo[3,2-D]Pyrimidine 6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine 6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 6-Chloropyrimidin-4-Amine 7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine 7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine 7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine [1,2,4]Triazolo[1,5-A]Pyrimidine Ethyl 4-Chloropyrimidine-5-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Ethyl Pyrimidine-4-Carboxylate Ethyl Pyrimidine-5-Carboxylate Imidazo[1,2-C]Pyrimidine Methyl Pyrimidine-2-Carboxylate Methyl Pyrimidine-4-Carboxylate Methyl Pyrimidine-5-Carboxylate N,N-Dimethylpyrimidin-2-Amine N-(9-((2R,5S)-5-((Trityloxy)Methyl)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide N-Benzyl-9H-Purin-6-Amine N-Cyclopropylpyrimidin-2-Amine N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide N-Methylpyrimidin-2-Amine N-Methylpyrimidin-4-Amine N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine N-Phenylpyrimidin-2-Amine N-Phenylpyrimidin-4-Amine N2,N4-Diphenylpyrimidine-2,4-Diamine Pyrido[2,3-D]Pyrimidine Pyrido[3,2-D]Pyrimidine Pyrido[3,4-D]Pyrimidine Pyrimidin-2-Ol Pyrimidin-2-Ylmethanamine Pyrimidin-2-Ylmethanol Pyrimidin-4-Amine Pyrimidin-4-Ol Pyrimidin-5-Amine Pyrimidin-5-Ol Pyrimidin-5-Ylboronic Acid Pyrimidine-2,4-Diamine Pyrimidine-2-Carbonitrile Pyrimidine-2-Carboxylic Acid Pyrimidine-2-Thiol Pyrimidine-4,6(1H,5H)-Dione Pyrimidine-4-Carbonitrile Pyrimidine-4-Carboxylic Acid Pyrimidine-5-Carbaldehyde Pyrimidine-5-Carbonitrile Pyrimidine-5-Carboxylic Acid Tetrahydropyrimidin-2(1H)-One Thiazolo[5,4-D]Pyrimidine Thieno[2,3-D]Pyrimidine Thieno[3,2-D]Pyrimidine

By Key Group+−

Allylpyrimidine Amino-Pyrazolopyrimidine Amino-Pyrrolopyrimidine Amino-Triazolopyrimidine Aminopyrimidine Benzofuranopyrimidine Bipyrimidine Bromo-Pyrazolopyrimidine Bromo-Pyrrolopyrimidine Bromo-Trifluoromethyl-Pyrimidine Bromopyrimidine Butylpyrimidine Chloro-Pyrazolopyrimidine Chloro-Pyrrolopyrimidine Chloro-Triazolopyrimidine Chloro-Trifluoromethyl-Pyrimidine Chloropyrimidine Cyclopropylpyrimidine Diaminopyrimidine Dibromopyrimidine Dichloropyrimidine Difluoropyrimidine Dihydropyrimidine Dihydroxy-Pyrimidine Dihydroxypyrimidine Dimethoxypyrimidine Dimethylpyrimidine Dioxaborolan-Pyrimidine Diphenylpyrimidine Ethoxypyrimidine Ethylpyrimidine Fluoropyrimidine Furanopyrimidine Hydrazinylpyrimidine Hydroxy-Pyrazolopyrimidine Hydroxypyrimidine Imidazolyl-Pyrimidine Imidazopyrimidine Iodo-Pyrrolopyrimidine Iodopyrimidine Isopropoxypyrimidine Isopropylpyrimidine Mercaptopyrimidine Methoxypyrimidine Methyl-Triazolopyrimidine Methylpyrimidine Methyluracil Nitropyrimidine Phenoxypyrimidine Phenylpyrimidine Piperazin-Pyrimidin Piperidine-Pyrimidine Propylpyrimidine Pyrazolo-Pyrimidine Pyrazolopyrimid-One Pyrazolopyrimidine Pyridin-Pyrimidin Pyridopyrimidin Pyrimidinamine Pyrimidine-Boronic Acid Pyrimidine-Boronic Acid/Ester Pyrimidine-Boronic-Acid Pyrimidine-Hydrochloride Pyrimidine-Methanol Pyrimidine-Morpholine Pyrimidine-Nitrile Pyrimidine-Pyrazole Pyrimidinecarbonitrile Pyrimidinecarboxylate Pyrimidinecarboxylic Pyrimidinone Pyrimido-Indole Pyrrolidine-Pyrimidine Pyrrolopyrimidin-One Pyrrolopyrimidine Pyrrolopyrimidine-Carboxylate Pyrrolopyrimidine-Carboxylic-Acid Tetrahydrofuran-Pyrimidine Tetrahydropyrimidine Tetraoxatetradecan Thiazo-Pyrimidine Thiazolopyrimidine Thiazopyrimidine Thienopyrimidine Triazolopyrimidine Trichloropyrimidine Trifluoromethyl-Phenyl-Pyrimidin Trifluoromethyl-Pyrimidin-Amine Trifluoromethyl-Pyrimidin-Ol Trifluoromethylpyrimidine Vinylpyrimidine

By Parent Nucleus+−

Aromatic Heterocycles Azetidines Benzimidazoles Imidazoles Indazoles Indoles Indolines Morpholines Piperazines Piperidines Pyrazoles Pyridines Pyrrolidines Tetrahydroisoquinolines Thiazoles Thiophenols Triazoles

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pyr

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